The 2025 Nobel Prize in Physiology or Medicine has been awarded to Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi for their pioneering research on peripheral immune tolerance, the Nobel Assembly announced on Monday.
Their landmark discoveries have deepened scientific understanding of how the immune system differentiates between the body&rsquo;s own cells and foreign invaders &mdash; a process essential to preventing autoimmune diseases.
According to the Nobel Committee, the trio&rsquo;s findings have laid the foundation for developing innovative therapies for autoimmune disorders, organ transplant rejection, and chronic inflammation.
The announcement marks the beginning of the 2025 Nobel Prize season, one of the most awaited scientific events of the year. 
Prizes in physics, chemistry, literature, peace, and economics will follow in the coming days.

Nobel laureates honored for immune tolerance discovery

Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi win Nobel for immune tolerance research

Brunkow, Ramsdell, Sakaguchi Win 2025 Nobel

Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi win Nobel for immune tolerance research

October 6, 2025 | 15:42 IST